†equal contribution *corresponding authors
Gabriel Manzanarez†, Rohan Balakrishnan†, Harish Kannan†, Miriam Abele, Hiroyuki Okano, Fukang She, Zhongge Zhang, Chenhao Wu, Lance Freiman, Christina Ludwig*, Matteo Mori* and Terence Hwa*. Global proteolysis during starvation governs proteome remodeling and a survival–regrowth trade-off in bacteria. Proc Natl Acad Sci (2026).
Rohan Balakrishnan* and Jonas Cremer*. Conditionally unutilized proteins and their profound effects on growth and adaptation across microbial species. Current Opinion in Microbiology (2023).
Guessous, G., Patsalo, V., Balakrishnan, R., Çağlar, T., Williamson, J. R., Hwa, T. Inheritance of secreted enzymes enables the sustained growth of dispersing marine bacteria on chitin particles. Nature Microbiology (2023).
Balakrishnan, R†., Mori, M†., Segota, I., Zhang, Z., Okano, H., Aebersold, R., Ludwig, C., Hwa, T. Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria. Science (2022).
Wu, C†., Balakrishnan, R†., Braniff, N., Mori, M., Manzanarez, G., Zhang, Z., Hwa, T. Cellular perception of growth rate and the mechanistic origin of bacterial growth laws. Proc Natl Acad Sci (2022).
Balakrishnan, R*., de Silva, RT., Hwa, T., Cremer, J*. Suboptimal proteome allocation during changing environments constrains bacterial response and growth recovery. Mol Syst Biol (2021).
Dai, X., Zhu, M., Warren, M., Balakrishnan, R., Okano, H., Williamson, J. R., Fredrick, K., Wang, YP., Hwa, T. Slowdown of Translational Elongation in Escherichia coli under Hyperosmotic Stress. mBio (2018).
Gibbs, M. R., Moon, K. M., Chen, M., Balakrishnan, R., Foster, L. J., & Fredrick, K. Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome. Proc Natl Acad Sci (2017).
Dai, X., Zhu, M., Warren, M., Balakrishnan, R., Patsalo, V., Okano, H., Williamson, J. R., Fredrick, K., Wang, YP., Hwa, T. Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nature Microbiology (2016).
Fleming, I. M., Paris, Z., Gaston, K. W., Balakrishnan, R., Fredrick, K., Rubio, M. A., & Alfonzo, J. D. A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. Sci rep (2016).
Balakrishnan, R.†, Oman, K†., Shoji, S., Bundschuh, R., and Fredrick, K. The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli. Nucleic Acids Res (2014).